Phenylpropanoids and polyketides
Medchemexpress LLC Sodium benzoate | 532-32-1 | MFCD00012463 | ≥98.0% | 25g
Sodium benzoate is an orally active pharmaceutical excipient such as an antibacterial agent preservative lubricant etc Pharmaceutical excipients or pharmaceutical auxiliaries refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations which can improve the stability solubility and processability of pharmaceutical preparations Pharmaceutical excipients also affect the absorption distribution metabolism and elimination (ADME) processes of co-administered drugs Sodium benzoate activates NF- B and induces Apoptosis Sodium benzoate induces immune suppression and produces reproductively toxic Sodium benzoate can be used for colon cancer and immune disease research[1][2][3][4][5]
Medchemexpress LLC 3',4'-dimethoxy-α-naphthoflavone | 14756-24-2 | MFCD00143008 | 98.5% | 332.35 | C21H16O4 | 25 MG
DiMNF (3',4'-Dimethoxy-αNF) is a selective aryl hydrocarbon receptor (AHR) modulator used in laboratory research. It acts as a competitive AHR ligand with a reported IC50 = 21 nM and exhibits apparent antagonistic activity; it is applied in studies of AHR-mediated signaling and inflammatory responses. For research use only.
- Competitive AHR ligand (IC50 = 21 nM).
- Used to study AHR signaling and inflammation.
- High purity (98.46%).
- Molecular formula C21H16O4; molecular weight 332.35.
- Available as solids (including 25 mg) and as 10 mM solutions in DMSO.
- Intended for laboratory research only; not for human use.
Medchemexpress LLC Methyl 4-hydroxy-3-methoxycinnamate | 2309-07-1 | MFCD00017208 | 99.9% | 208.21 g·mol⁻¹ | C11H12O4 | 500 MG
Ferulic acid methyl ester (methyl ferulate) is the methyl ester derivative of ferulic acid (CAS 2309-07-1). It is used as a research reagent with reported antioxidant and anti-inflammatory activity and has been reported to affect p38 MAPK; supplied for biochemical and cellular studies at high purity.
- Methyl ester derivative of ferulic acid.
- Reported antioxidant and anti-inflammatory activity.
- Reported activity in p38 MAPK assays.
- High purity suitable for biochemical and cellular research.
- Soluble in common organic solvents such as DMSO.
- Available in small research pack sizes (for example, 500 mg).
eMolecules 2-(Methanesulfonyl(N-methoxymethyl)amino)pyrimidine-5-boronic acid, pinacol ester | 2096333-95-6 | MFCD19684127 | 1g
Combi-Blocks | 2-(Methanesulfonyl(N-methoxymethyl)amino)pyrimidine-5-boronic acid, pinacol ester | 1g | 117545104 | PN-4006 | 96.000 | 2096333-95-6 | MFCD19684127 | 343.210 | C13H22BN3O5S
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Medchemexpress LLC 3-Methylflavone-8-carboxylic acid | 3468-01-7 | 99.8% | 280.28 | 50 G
3-Methylflavone-8-carboxylic acid is a biochemical reagent used as a biological material or organic compound for life science related research. It is for research use only.
- Biochemical reagent for life science research
- Suitable as a biological material or organic compound
- Not for clinical or patient use
Selleck Chemical LLC STX-478-E1815-100MG
STX-478 is a highly potent mutant-selective allosteric inhibitor of PI3K that selectively targets prevalent mutant forms of PI3K It demonstrates strong efficacy against common PI3K helical- and kinase-domain mutations including the H1047R variant with an IC50 value of 9 4 nmol/L STX-478 exhibits 14-fold greater selectivity for mutant PI3K over the wild-type form It spares metabolic dysfunction and improves therapeutic response in PI3K -Mutant Xenografts
Medchemexpress LLC Acacetin, 5,7-dihydroxy-4'-methoxyflavone | 480-44-4 | 284.26 | 100 MG
Acacetin is an orally active flavonoid derived from *Dendranthema morifolium*. It acts by docking in the ATP binding pocket of PI3Kγ. Acacetin induces cell cycle arrest, apoptosis, and autophagy in cancer cells.
- Possesses potent anti-cancer and anti-inflammatory activity.
- Has potential for research into pain-related diseases.
- Decreases cancer cell viabilities in a dose-dependent manner.
- Induces apoptosis and autophagy.
Medchemexpress LLC Catechin (Standard) | 154-23-4 | 290.27 | 25 MG
Catechin (Standard) is the analytical standard of Catechin, intended for research and analytical applications. It inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. The compound is an analytical standard grade used as a reference standard for assays and is commonly employed in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Analytical standard for Catechin
- Intended for research and analytical applications
- Inhibits cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM
- Used in qualitative, quantitative, and methodological research experiments in HPLC, GC, and MS
- Reference standard supplied assay
Medchemexpress LLC Rutin (Rutoside) | 153-18-4 | 610.52 | 500 MG
Rutin (Rutoside) is a flavonoid found in many plants. It exhibits a wide range of biological activities including anti-inflammatory, antidiabetic, antioxidant, neuroprotective, nephroprotective, hepatoprotective, and reducing Aβ oligomer activities. It is also a CBR1 inhibitor and can cross the blood-brain barrier. Rutin attenuates vancomycin-induced renal tubular cell apoptosis by suppressing apoptosis, mitochondrial dysfunction, and oxidative stress.
- Anti-inflammatory activity
- Antidiabetic activity
- Antioxidant activity
- Neuroprotective properties
- Nephroprotective properties
- Hepatoprotective properties
- Reduces Aβ oligomer activities
- CBR1 inhibitor
- Can cross the blood-brain barrier
- Attenuates vancomycin-induced renal tubular cell apoptosis
Medchemexpress LLC Hesperetin 7-O-glucoside | 31712-49-9 | MFCD20275042 | 99.4% | 464.42 g/mol | C22H24O11 | 50MG
Hesperetin 7-O-glucoside is a flavanone monoglucoside derived from citrus flavonoids used in biochemical research. It demonstrates anti-inflammatory and orally active antihypertensive effects, inhibits human intestinal maltase and HMG-CoA reductase, and has reported antibacterial and gut microbiome-modulating activity. Supplied as a solid for laboratory research applications.
- High purity suitable for research (99.4%).
- Molecular formula C22H24O11, molecular weight 464.42 g/mol.
- Demonstrated inhibition of intestinal maltase and HMG-CoA reductase.
- Shows anti-inflammatory and antihypertensive activities.
- Reported antibacterial effects and regulation of intestinal flora.
- Available in small quantities for experimental use (1 mg-100 mg).
Apexbio Technology LLC Formononetin 485-72-3 20mg
Formononetin (CAS 485-72-3) is an isoflavone primarily derived from red clover (Trifolium pratense) This compound exhibits biological activity against Giardia lamblia by promoting the detachment of trophozoites from the intestinal mucosa thereby disrupting the parasite s adherence and colonization Formononetin is utilized in research investigating anti-parasitic mechanisms host-pathogen interactions in intestinal infections and the broader pharmacological effects of dietary isoflavones Its distinct mode of action supports studies on novel approaches for protozoal infection treatment and the modulation of host cell-pathogen attachment
Medchemexpress LLC 2-methoxycinnamaldehyde | 1504-74-1 | MFCD00007001 | 162.19 g/mol | C10H10O2 | 1 G
2-Methoxycinnamaldehyde analytical standard for research use. Molecular formula C10H10O2, molecular weight 162.19 g/mol. Store at -20°C under nitrogen; in solvent: -80°C for up to 6 months or -20°C for 1 month (under nitrogen).
- Analytical standard suitable for analytical and research applications.
- Supplied in small pack sizes for reference use.
- Stable when stored under recommended conditions.
- Intended for research use only; not validated for medical applications.
Medchemexpress LLC 2-methoxycinnamaldehyde | 1504-74-1 | 98.0% | 162.19 g·mol⁻¹ | C10H10O2 | 500 MG
2-Methoxycinnamaldehyde is a phenylpropanoid aldehyde supplied as a solid research reagent for in vitro and biochemical studies. It has reported activity against topoisomerase I/II and NF-κB signaling and is provided in small pack sizes for laboratory use.
- High purity: 98.0% (product data sheet).
- Molecular formula: C10H10O2; molecular weight: 162.19 g·mol⁻¹.
- Appearance: solid, white to yellow.
- Available pack sizes include 500 MG and other small-scale quantities.
- Storage recommendations: store under nitrogen at -20°C; in solvent: -80°C (6 months), -20°C (1 month).
Medchemexpress LLC AMG 487 | 473719-41-4 | C32H28F3N5O4 | 100 MG
AMG 487 is an orally active and selective antagonist of CXC chemokine receptor 3 (CXCR3). It inhibits the binding of CXCL10 and CXCL11 to CXCR3 with IC50s of 8.0 and 8.2 nM, respectively.
- Targets CXCR3
- Involved in GPCR/G Protein and immunology/inflammation pathways
- Inhibits CXCR3-mediated cell migration
- Inhibits calcium mobilization
- Leads to fewer lung metastases
- Reduces tumor volume
Selleck Chemical LLC Genistin (Genistoside) S2301-50mg
Genistin (Genistoside Genistine Genistein 7-glucoside Genistein glucoside) is an isoflavone found in a number of dietary plants like soy and kudzu Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of Estrogen Receptor (ER ) signaling pathway